06/01/2018 **The study has been successfully enrolled. Screening is now Closed.**
ANNOUNCING A CLINICAL TRIAL OPPORTUNITY FOR INDIVIDUALS WITH PCD:
Parion Sciences and Vertex Pharmaceuticals announce the CLEAN-PCD trial of a novel inhaled compound (VX-371) designed to improve airway hydration and aid with clearance of mucus. CLEAN-PCD, an international clinical study, will evaluate the effectiveness of this compound in individuals with PCD. For more information about this particular study, please visit the official Clinical Trials site.
In PCD, ineffective ciliary function leads to stagnant mucus in the airways. Retained mucus is a breeding ground for infectious pathogens. Infection and inflammation in the airways triggers additional mucus production and the mucus becomes thicker and harder to remove. This creates a ‘vicious cycle’ of mucus hypersecrection, infection, inflammation and more mucus hypersecretion. The proposed mechanism of this investigational compound VX-371 is reducing the burden of this vicious cycle through more effective clearance of mucus.
To preserve the integrity of the data collected during the CLEAN-PCD trial, there are carefully selected inclusion (who can participate) and exclusion (who cannot) criteria for this study. Clinical studies seek to answer a clinical question(s) and to ensure that these questions are the only focus, careful attention is paid to prevent ‘confounding’ issues from arising. Inclusion and exclusion criteria for CLEAN-PCD can be found at the link below.
Please note that there are 35 centers in 8 countries participating in this trial so far and individuals who wish to participate will need to be seen at one of these centers.
The study design for CLEAN-PCD ensures that every participant will be on the investigational drug at some point during the trial. There will be two phases–one on drug or placebo, followed by a washout period, and then the second phase where participants will receive either the drug or placebo they did not get in phase I.
The goal of research is to provide generalized knowledge that can be applied to a population under study. This is different than a therapeutic relationship with your own doctor, which is designed to help you as an individual. You may not personally benefit from participating in research. Choosing not to participate in a clinical trial will not affect your relationship with your healthcare provider or with the PCDF. It is a strictly personal decision.
06/01/2018 The study has been successfully enrolled. Screening is now Closed.
The following sites are now activated for screening patients. If you are interested in participating in the study at any of these sites, please contact the Vertex patient line or the Parion study coordinator:
Medical Information 617-341-6777 / firstname.lastname@example.org
Ashley Simmons: 919-313-1210 / email@example.com
Check back frequently for updates. A map with all participating sites is posted below.
DISCLAIMER: Information about the CLEAN-PCD study is provided for information only and does not constitute an endorsement by the PCDF.
George Solomon, MD
University of Alabama Birmingham
Carlos Milla, MD & Jackie Zirbes, RN
Palo Alto, CA
Scott Sagel, MD & Carol Kopecky, RN
Mattias Salathe, MD & Patricia Graham, RN
University of Miami
Marisa Couluris, MD
University of South Florida/Morsani College of Medicine
Hugo Escobar, MD & Candy Schmoll, RN, BSN, CCRC
Children’s Mercy Hospital
Kansas City, MO
Deepika Polineni, MD
University of Kansas
Kansas City, KS
Mary Nevin, MD
Lurie Children’s Hospital
Michelle Prickett, MD
Northwestern Memorial Hospital
Stephanie Davis, MD
Riley Hospital fro Children at Indiana University Health
Douglas Hornick, MD
University of Iowa
Iowa City, IA
Kenan Haver, MD
Boston Children’s Hospital
Thomas Saba, MD
University of Michigan
Ann Arbor, MI
Anne Griffiths, MD
Children’s Minnesota Research
Thomas Ferkol, Jr, MD
Washington University in St. Louis
St. Louis, MO
Angela Dimango, MD
Columbia University Medical Center – New York Presbyterian Hospital
New York, NY
Margaret Leigh, MD
University of North Carolina at Chapel Hill
Chapel Hill, NC
Steven Strausbaugh, MD & Laura Veri, RN
UHCMC/Rainbow Babies & Children’s Hospital
Sharon Dell, MD
Hospital for Sick Children
Trey Brown, MD
USC Pediatric Research
Anne O’Donnell, MD
MedStar Georgetown University Hospital
Margaret Rosenfeld, MD
Adam Shapiro, MD
Health Centre for Innovative Medicine